Singh, R.#, Meng, H.#, Shen, T., Lumahan, L, Nguyen, S., Shen, H, Dasgupta, S., Qin, L., Karri, D., Zhu, B., Yang F., Coarfa, C., O’Malley B.W., Yi, P. (2023) TRAF4-mediated non-proteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer. Proceedings of the National Academy of Sciences 120, e2218229120. Available here https://tinyurl.com/4fun9pyj #Equal Contribution
Lv, X., Lu, X., Cao, J., Luo, Q., Ding, Y., Peng, F., Pataer, A., Lu, D., Han, D., Malmberg, E., Chan, D.W., Wang, X., Savage, S.R., Mao, S., Yu, J., Peng, F., Yan, L., Meng, H., Maneix, L., Han, Y., Chen, Y., Yao, W., Chang, E.C., Catic, A., Lin, X., Miles, G., Huang, P., Sun, Z., Burt, B., Wang, H., Wang, J., Yao, Q.C., Zhang, B., Roth, J.A., O’Malley B.W., Ellis, M.J., Rimawi, M.F., Ying, H., Chen, X. (2023) Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors. Science, Available here https://tinyurl.com/3zhh5u34
Meng, H.*, Gonzales, N.M., Jung, S.Y., Lu, Y., Putluri, N., Zhu, B., Dacso, C.C., Lonard, D.M., O’Malley, B.W.* (2022) Defining the mammalian coactivation of hepatic 12-hour clock and lipid metabolism. Cell Reports 38, 110491. Available here https://tinyurl.com/5eu6en5z *Corresponding Author
Meng, H., Gonzales, N.M., Lonard, D.M., Putluri, N., Zhu, B., Dacso, C.C., York, B., O'Malley, B.W. (2020). XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nature Communications 11, 6215. Available here https://tinyurl.com/aztx6cj7
Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S.M., Abdurehman, L., York, B., Chen, X., Schnytzer, Y., Levy, O., Dacso, C.C., McClung, C.A., O’Malley, B.W., Liu, S., Zhu, B. (2020). 12-h clock regulation of genetic information flow by XBP1s. PLoS Biology 18, e3000580. Available here https://tinyurl.com/y8xt6yrv
Meng, H., Harrison, D.J., and Meehan, R.R. (2015). MBD4 interacts with and recruits USP7 to heterochromatic foci. Journal of Cellular Biochemistry 116, 476-485. Available here https://tinyurl.com/bkf8fjv5
Meng, H.*, and Bartholomew, B.* (2018). Emerging roles of transcriptional enhancers in chromatin looping and promoter-proximal pausing of RNA polymerase II. Journal of Biological Chemistry 293, 13786-13794. Available here https://tinyurl.com/69fdmkxe
Meng, H.*, Cao, Y., Qin, J., Zhang, Q., Shi, Y., and Cao, L.* (2015). DNA methylation, its mediators and genome integrity. International journal of biological Sciences 11, 604-617. *Corresponding Author Available here https://tinyurl.com/ktecxyvd
Meng, H.*, Chen, G., Gao, H.M., Song, X., Shi, Y., and Cao, L.* (2014). The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neurons. International journal of molecular sciences 15, 22604-22625. Available here https://tinyurl.com/st3ww3k *Corresponding Author
Meng, H., Hackett, J.A., Nestor, C., Dunican, D.S., Madej, M., Reddington, J.P., Pennings, S., Harrison, D.J., and Meehan, R.R. (2011). Apoptosis and DNA methylation. Cancers (Basel) 3, 1798-1820. Available herehttps://tinyurl.com/uza3xxr5
Meng, H., and Meehan, R.R. (2011). MBD4 (Methyl-CpG Binding Domain Protein 4). Atlas of genetics and cytogenetics in oncology and haematology 15(12):1041-1044. Available here https://tinyurl.com/uv2v8dr2
EMBO Conference Series Chromatin and Epigenetics, Heidelberg, Germany.
Poster, “Functional Analysis of Methyl-CpG Binding Glycosylase MBD4”
Epigenome Network of Excellence (NoE) Annual Meeting, Edinburgh, U.K.
Poster, “Influence of Cytosine Oxidation and Deamination Analogues within CpG Dinucleotides
Clinical Neuroscience Conference, Edinburgh, U.K.
Poster, “Combination Strategies of Stem Cell Transplantation in Amyotrophic Lateral Sclerosis”
Neuroscience Network Annual Conference, Edinburgh, U.K.
Poster, “Pre- and Post-Synaptic Inhibitory Mechanisms Acting on Injury-Activated Nociception”
Neuroscience Network Annual Conference, Edinburgh, U.K.
Poster, “Synapse Clustering and Proximity in Integrated Protein Interaction Networks”
PhD Research Thesis in Cancer Epigenetics and Molecular Pathology, MRC Human Genetics Unit, University of Edinburgh, U.K.
"Functionally characterized a methyl-CpG binding DNA glycosylase; Methyl-CpG binding domain protein 4" - dissecting the activity of two methyl-CpG binding proteins, MBD4 and MeCP2, towards a better understanding of their pathogenic roles in human cancer
MSc Research Thesis in Artifitial Intellegence, School of Informatics, University of Edinburgh, U.K.
"Prioritization of genes for involvement in schizophrenia and bipolar disorder" - developing a synapse clustering algorithm and program for memory based on proximity in protein interaction networks.