GC-CPEH Subsidy Program under Award NIEHS 5P30ES030285-04 03/01/2021 – 12/31/2022
Spatial-temporal regulation of transcriptional activity by metabolic pathway enzymes in NASH/HCC.
The major goal of this study is to investigate the role of a new phosphorylation pathway regulated by metabolic enzymes in the development of non-alcoholic steatohepatitis (NASH) and NASH-driven hepatocellular carcinoma (HCC).
PI: Meng H.
Pilot Project Program under Award Number NIEHS P30ES0302852018. 03/01/2021 – 12/31/2022
Effects of arsenic exposure on mammalian 12-hour clock and NAFLD
The goal of this study is to define the role of endocrine disrupting chemicals (EDCs) in promoting human NAFLD and pre-diabetic syndromes.
PI: Meng H.; Senior PI mentor: O’Malley B.W.
1 P01 DK113954 (O’Malley) 07/01/2018 – 04/30/2024
NIH/NIDDK “Nuclear receptors and their Coactivators as Mediators of Systems Metabolism”
The goal of the research is to elucidate the mechanisms by which transcriptional coactivators direct the metabolic actions of nuclear receptor and transcription factor signaling to impact whole body energy balance.
Project Leader: Meng H.; PI: O’Malley B.W.
5 R01 HD008188 (O’Malley) 04/01/2020 – 03/31/2024
NIH/NICHD “Reproductive Hormones: Biological and Molecular Actions”
The major goals of this project are to characterize the interaction of hPR and hER with general cellular transcription coactivators in reproductive tissues.
PI: O’Malley B.W.
2 R01 HD007857 (O’Malley) 03/15/2017 – 02/28/2022
NIH/NICHD “Sex Hormone Receptor Components & Cell Genome”
The major goals are: To continue studies of transcriptional regulation by sex hormone receptors and their related family members and develop new transgenic models to dissect receptor/coactivator actions in vivo.
PI: O’Malley B.W.
Brockman Medical Research Foundation (O’Malley) 09/01/2016 – 08/31/2019
Towards ameliorating chronic disease. The goal of this study is to use OMICs platforms in combination with mouse and cell models to examine the progression of human chronic disease.
PI: O’Malley B.W.